Research
OUR RESEARCH
From viral entry to protective immunity.
The Zehner Lab investigates how human B cells and antibodies respond to human cytomegalovirus (HCMV) and other herpesviruses. From viral entry and immune evasion to therapeutic antibodies, we aim to understand how the immune system controls infection and to translate this knowledge into new strategies for prevention and therapy.
B-cell & antibody responses
How B cells are activated, diversify their antibodies, and form long-lived immunity.
FROM MECHANISTIC INSIGHT TO DURABLE PROTECTION.
From molecules to mechanisms
We connect viral entry, immune evasion and B-cell recognition to understand how infection shapes protective immunity.
Viral entry & immune evasion
How herpesviruses enter cells and avoid recognition by the immune system.
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From response to memory
We trace how B-cell activation, clonal selection and antibody maturation establish durable antiviral immune memory.
Therapeutic antibodies
Discovery and characterization of broadly neutralizing and therapeutic antibodies.
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From insight to intervention
We translate mechanistic insight into the discovery and characterization of broadly neutralizing and therapeutic antibodies.
FOCUS AREA
Immunology of HCMV infection
Our research focuses on the investigation of the human B-cell response in HCMV infections, thereby identifying relevant target structures among viral proteins which are responsible for high neutralizing activity and interfering with transmission in infected patients. Using state-of-the-art techniques, we aim to broaden the knowledge on HCMV epitopes with strong immunogenicity to provide new targets for specific therapeutic approaches and vaccine development.
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From mechanistic insight to durable protection.
EXPANDING OUR SCOPE
Beyond CMV
While CMV is a major focus, we also study B-cell and antibody responses to other herpesviruses and emerging pathogens. Comparative analyses help us identify shared and unique immune mechanisms, guiding the development of broadly effective antiviral strategies.
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